Our Mission
The Thalion Initiative is focused on improving the fundamental understanding of aging biology to enhance drug development and therapeutic interventions. By integrating diverse scientific disciplines, we aim to advance research methodologies and develop practical applications for aging-related conditions.
Key Objectives
Investigate fundamental mechanisms of aging
Improve predictability in biology
Enforce interdisciplinary collaboration for more effective research approaches
Why Thalion?
We apply a first-principles approach to aging biology, incorporating comparative biology, synthetic biology, and embryonic rejuvenation to address knowledge gaps. We prioritize open access to data and tools, enabling collaborative progress across the scientific community.
Eroom’s Law
Drug development costs continue to rise, while success rates decline
High Failure Rates
Only a small fraction of pre-clinical candidates lead to approved therapeutics
Limited Disruptive Progress
Most scientific advancements build incrementally rather than introducing fundamentally new approaches
Aging is a key driver of many chronic diseases, including cancer, cardiovascular conditions, and neurodegeneration. Addressing aging mechanisms will lead to broader health benefits compared to treating individual diseases in isolation.
We employ a systems-based methodology to improve aging research by focusing on
Validating the Central Dogma of Biology
New research to elucidate the central dogma of biology.
Advanced Tool Development
Improving real-time measurement technologies for aging biomarkers while enhancing predictive modeling and simulation capabilities.
Experimental Insights
Identifying shared biological mechanisms across species to improve therapeutic predictability through quantitative modeling.
A Phased RESEARCH Strategy
focus areas
Comparative Biology
Studying longevity and disease resistance in different species.
Synthetic Biology
Engineering biological functions to mitigate aging mechanisms.
Advanced Tooling
Developing new measurement and modeling technologies for aging research.
Embryonic Rejuvenation
Investigating natural regenerative processes in early development.